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Animal Models for the Study of Human Disease. Antifibrotic Activity of Acylated and Unacylated Ghrelin. International Journal of Endocrinology ; Reversal of liver fibrosis: From fiction to reality. Journal of Lipid Research ; 54 M 22 Charlotte J. Green, Camilla Pramfalk, Karl J. From whole body to cellular models of hepatic triglyceride metabolism: American Journal of Physiology-Endocrinology and Metabolism ; 1: Journal of Medicinal Food ; 17 2: The American Journal of Pathology ; 3: Time-course metabolic changes in high-fat diet-induced obesity rats: A pilot study using hyperpolarized 13C dynamic MRS.
Magnetic Resonance Imaging ; 34 8: Obesity, Fatty Liver and Liver Cancer. Advances in Experimental Medicine and Biology ; Molecular Biology of the Cell ; 26 Assessing inflammatory liver injury in an acute CCl4model using dynamic 3D metabolic imaging of hyperpolarized [C]pyruvate. NMR in Biomedicine ; 28 Heilig, Carolyn Lowe, Jonathan D.
Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment. Involvement of senescence marker protein in glucose metabolism disorder and non-alcoholic fatty liver disease. Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet.
Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: The American Journal of Clinical Nutrition ; 3: Hepatology ; 61 1: Lionarons, Michal Heger, Rowan F. Simple steatosis sensitizes cholestatic rats to liver injury and dysregulates bile salt synthesis and transport.
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Inhibition of ceramidede novosynthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease. Liver International ; 34 7: Ferslew, Weibin Zha, Bobbie K. Sidney Barritt, Darryl C. Characterization of the Cytochrome P epoxyeicosanoid pathway in non-alcoholic steatohepatitis.
Integrative transcriptomic analysis of NAFLD animal model reveals dysregulated genes and pathways in metabolism. Gene ; 1: Deletion of exons 3 and 4 in the mouse Nr1d1 gene worsens high-fat diet-induced hepatic steatosis.
Life Sciences ; A novel diet-induced murine model of steatohepatitis with fibrosis for screening and evaluation of drug candidates for nonalcoholic steatohepatitis. Physiological Reports ; 4 Mediators of Inflammation ; Fedor, Yuriko Adkins, John W.
Metabolic Syndrome and Related Disorders ; 11 1: Role of folate in nonalcoholic fatty liver disease.
Canadian Journal of Physiology and Pharmacology ; 95 Nonalcoholic Fatty Liver Disease: Nutrients ; 10 1: Cancer Cell ; 30 1: Global publication trends and research hotspots of nonalcoholic fatty liver disease: Marginal iron deficiency enhances liver triglyceride accumulation in rats fed a high-sucrose diet.
Bioscience, Biotechnology, and Biochemistry ; 82 This aids in the assignment of pathogenicity to these human VUS and validates the approach described here as a diagnostic tool. In a wider perspective, this work provides a model We identified three variants associated with subjective well-being, two with depressive symptoms, and eleven with neuroticism, including two inversion polymorphisms. The two depressive symptoms loci replicate in an independent depression sample.
To further elucidate the genetic basis of XFS, we collected a global sample of XFS cases to refine the association at LOXL1, which previously showed inconsistent results across populations, and to identify new variants associated with XFS.
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We identified a rare protective allele at LOXL1 p. We identified association signals at 13q12 POMP11q These findings provide biological insights into the pathology of XFS and highlight a potential role for naturally occurring rare LOXL1 variants in disease biology. Okbay Aysu ; Baselmans, B. Turley Patrick ; M. Nivard Michel ; Fontana, M.
Mark Alan ; Meddens, S. Richard Karlsson ; Rietveld, C. Cornelius A ; J. Gratten Jacob ; J. Jimmy Z ; R. Tarunveer ; Buchwald, J. Cavadino Alana ; A. Nicholas A ; Garfield, V. Victoria ; Geisel, M.
Marie Henrike ; J. Karlsson Robert ; Der Laan, S. Sander Wvan ; K. Ladwig Karl-Heinz ; J. Lahti Jari ; S. Lind Penelope ; Liu, T.
Tian ; Matteson, L. Mihailov Evelin ; M. Miller Mike ; CMinica, C. Camelia ; MNolte, I. Mook-Kanamori Dennis ; P. Oldmeadow Christopher ; Y. Qian Yong ; O. Raitakari Olli ; R. Rico ; Schmidt, B. Smith Albert Vernon ; E. Stergiakouli Evangelia ; T.
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Tanaka Toshiko ; K. Taylor Kent ; Wedenoja, J. Juho ; Wellmann, J. Sara ; Zhao, W. Study LifeLines Cohort ; N. Amin Najaf ; Bakshi, A. Boyle Patricia ; Cherney, S. Samantha ; Cox, S. Simon R ; G. Davies Gail ; O. Ding Jun ; N. Direk Nese ; Eibich, P.
Emeny Rebecca ; Fatemifar, G. Ferrucci Luigi ; A. Forstner Andreas ; C. Gieger Christian ; Gupta, R. Harris Tamara ; J. Harris Juliette ; E. Holliday Elizabeth ; J. Hottenga Jouke Jan ; P. Kaakinen Marika ; E. Kajantie Eero ; Karhunen, V. Kolcic Ivana ; M.
Kumari Meena ; L. Launer Lenore ; L. Franke Lude ; Li-Gao, R.